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The valence of the microorganisms may be determined by pressing calmly on the cover slip with a pointed object just like the tip of a pen. When crimson blood cells grow to be infested with the upper valence progress types of the primary parasite, their urge to merge pulls the RBCs together. Copulation between high valence microorganisms on adjoining RBC membranes account for the rouleau formations. The presence of massive rouleau will be detrimental to patients affected by occlusive vascular diseases because it causes impairment of blood movement within the small vessels that may compromise the red blood sugar regulation formula cells’ capability to trade carbon dioxide and oxygen gases. This may cause greater blood sugar control supplement pressure in order to extend the supply of blood and oxygen to the tissue. Peripheral blood smears display rouleau when elements that enhance ESR (erythrocyte sedimentation charge) are current. Anemia, by growing the ratio of RBCs to plasma, increases rouleau formation and accelerates sedimentation.
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